Multiple choice At what stage of the cell cycle are histone proteins synthesized in a eukaryotic cell? During telophase During S–phase During G–2 stage of interphase During entire prophase Reveal answer Fill a bubble to check yourself C Correct answer Explanation G2 phase is a period of rapid cell growth and protein synthesis during which the cell readies itself for mitosis. So, during G–2 stage of interphase histone proteins synthesized in a eukaryotic cell.