Multiple choice At which stage of the cell cycle do histone proteins synthesise in a eukaryotic cell? During the S-phase During the prophase II During the telophase During the G-2 stage of prophase During the metaphase II Reveal answer Fill a bubble to check yourself A Correct answer Explanation During the S phase or synthetic phase the replication of DNA takes place. For replication of DNA histone proteins are required, so they are also synthesised during this phase. It takes about 30%-50% of the total cell cycle.