Collagen is the major insoluble fibrous protein in the extracellular matrix and in connective tissue. In fact, it is the single most abundant protein in the animal kingdom. Collagen, in the form of elongated fibrils, is mostly found in fibrous tissues such as tendon, ligament, and skin and is also abundant in cornea, cartilage, bone, blood vessels, the gut, and intervertebral disc. The fibroblast is the most common cell, which creates collagen.