Directions: In the following question, four statements are provided between an opening statement 1 and a closing statement 6. The four statements are jumbled up and form a coherent paragraph when properly arranged. Select the alternative representing the proper and logical sequencing of these six taken together.

1 Charaka observes that how these edible and potable substances can be rendered harmless. A. He stated that the way in which they are combined with other foods also matters a lot. B. Also, the way they are cooked affects the quality. C. He arrived at his conclusions after a careful study of the facts. D. Hence, care must be taken before mixing them. 6 Further, the mental state in which they are consumed is not insignificant.