Multiple choice Which of these statements concerning platelets is not true? They extrude their nucleus as they pass through the spleen. The megakaryocyte matures by endomitotic synchronous replication so that the number of nuclear lobes increases within the cell. Thrombopoietin is the major regulator of platelet production, and is produced by the liver and kidneys. The platelet lifespan is 7-10 days. The platelets provide phospholipid for the initiation of the coagulation process. Reveal answer Fill a bubble to check yourself A Correct answer Explanation This is an incorrect statement as the platelets bud off from megakaryocytes, and never have a nucleus.