Multiple choice

Which of the following single immunodeficiency disease affects CD4-positive T-cells ?

  1. The acquired immune deficiency syndrome (AIDS).

  2. Complete DiGeorge syndrome

  3. Purine nucleoside phosphorylase (PNP) deficiency

  4. Severe protein-calorie malnutrition

  5. Wiskott-Aldrich syndrome

Reveal answer Fill a bubble to check yourself
B Correct answer
Explanation

In complete DiGeorge syndrome there is a total failure of the thymus to develop and thus neither CD4-positive T-cells nor CD8-positive T-cells are formed. Note, however, that most cases of DiGeorge syndrome are 'partial' with some thymic development and thus not a complete absence of T-cells.

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