An young woman of 32 years is found to have a largely solid ovarian neoplasm. Tumor markers were obtained and demonstrated a markedly elevated LDH value. The hCG and a-Fetoprotein were negative. Which of the following tumors is the most likely histology for this neoplasm?
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Endodermal sinus tumor
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Choriocarcinoma
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Immature teratomas
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Gonadoblastoma
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Dysgerminomas
C
Correct answer
Explanation
Immature teratomas of the ovary are rare germ cell malignancies. These are frequently diagnosed in girls and young women up to their early 20s.
Dysgerminomas, the most frequent germ cell malignancy, are principally solid. Such tumors are most frequent in women with dysgenetic gonads. Pure ovarian dysgerminomas cause an elevated LDH with normal hCG and a-fetoprotein levels..