Multiple choice When prescribing drugs, which of the following factors does not come into play? Renal impairment does not have a major effect on drugs which are excreted by the liver . Renal impairment generally decreases tubular drug secretion. Renal impairment can increase the half life of a drug. It is common to have to increase the dose of a drug when there is renal impairment. Dialysis can remove some drugs . Reveal answer Fill a bubble to check yourself D Correct answer Explanation Commonly, the dose of a drug is reduced when there is renal impairment to prevent the accumulation of the drug. It is also common to reduce the frequency of the doses.