Multiple choice

Which of the following investigations is essential for the diagnosis of all solid B-cell tumors?

  1. Gene rearrangement study

  2. Detection of a thymoma

  3. Bone marrow/lymph node examination

  4. Analysis of urine for protein

  5. X-ray of the skull
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C Correct answer
Explanation

The diagnosis of all circulating B cell tumours relies on the involvement of the bone marrow. However for solid tumours, such as Hodgkin's disease and Non-Hodgkin's lymphoma, a lymph node biopsy is the essential investigation, though bone marrow trephine is often done to assess stage

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