The pattern multiplies each number by an increasing integer and then alternates adding and subtracting 1: 20 × 1 + 1 = 21, 21 × 2 + 1 = 43, 43 × 3 + 1 = 130 (not 140), 130 × 4 + 1 = 521, and 521 × 5 + 1 = 2606. The correct number should be 130 instead of 140.