This requires the binomial distribution formula, where the probability of exactly r successes in n trials is given by nCr * p^r * q^(n-r). For exactly 2 tails in 6 tosses, we calculate 6C2 * (1/2)^2 * (1/2)^4. This evaluates to 15 * (1/4) * (1/16) = 15/64.