The center of the circle x squared plus y squared minus 4x minus 2y minus 40 equals 0 is (2, 1). A chord making an angle whose tangent is 4/3 with the x-axis has a slope of 4/3, and the locus of the middle points of such chords is perpendicular to the chords and passes through the center. The slope of this locus is the negative reciprocal of 4/3, which is minus 3/4, so using the point-slope form through (2, 1) gives y minus 1 equals minus 3/4 times (x minus 2). Multiplying by 4 and rearranging yields the equation 3x plus 4y equals 10.