The series is 22, 24, 28, ?, 52, 84. The differences are: 24-22=2, 28-24=4. These differences double each time: 2, 4, so the next difference should be 8, making the missing number 28+8=36. Continuing: 36+16=52, and 52+32=84, which matches the given numbers. Options A, C, and D don't fit this doubling difference pattern.