TROUBLE has 7 letters with vowels O, U, E (3 vowels) and consonants T, R, B, L (4 consonants). Treat vowels as one block: [OUE] T R B L. This gives 5! = 120 arrangements of blocks. Within the vowel block, 3 vowels can be arranged in 3! = 6 ways. Total = 120 × 6 = 720.