The surface area of a cube is calculated by the formula 6s^2, where s is the edge length. For a cube with edge 4 cm: 6 x (4 cm)^2 = 6 x 16 cm^2 = 96 cm^2. Option A (64 cm^2) would be the volume (4^3), option C (16 cm^2) is just s^2, and option D (48 cm^2) might result from incorrectly using 3s^2 instead of 6s^2.